> ## Documentation Index > Fetch the complete documentation index at: https://docs.catalog.igvf.org/llms.txt > Use this file to discover all available pages before exploring further. # Genes Variants > Retrieve variant-gene pairs including eQTLs & splice QTLs from AFGR and eQTL Catalogue, and CRISPR screen and Variant-EFFECTS from IGVF, by Ensembl gene ids. The following parameters can be used to set thresholds on -log10 p_value: gt (>), gte (>=), lt (\<), lte (\<=). Set verbose = true to retrieve full info on the corresponding variants and genes. At least one of these properties must be defined: gene_id, hgnc_id, gene_name, region, alias, method, or files_fileset. The limit parameter controls the page size and can not exceed 500. Pagination is 0-based. **Examples by method** These examples are grouped by method; use the `method` filter to return data from a specific method. **eQTL:** **Single result** - gene_id = ENSG00000187642 - neg_log10_pvalue = gte:24.5 - method = eQTL **Group results** - alias = PERM1 - method = eQTL **spliceQTL:** **Single result** - gene_id = ENSG00000188976 - neg_log10_pvalue = gt:45 - effect_size = gt:0.5 - method = spliceQTL **Group results** - alias = NOC2L - method = spliceQTL **Variant-EFFECTS:** **Single result** - gene_id = ENSG00000108179 - neg_log10_pvalue = gt:13.1 - method = Variant-EFFECTS **Group results** - alias = PPIF - method = Variant-EFFECTS **CRISPR screen:** **query by gene identifier** - gene_id = ENSG00000177455 - method = CRISPR screen **query by gene name** - gene_name = CD19 - method = CRISPR screen ## OpenAPI ````yaml /openapi/catalog-dev.openapi.json get /genes/variants openapi: 3.0.3 info: title: IGVF Catalog - Development description: >- Development IGVF Catalog OpenAPI compliant REST API built using tRPC with Express. Our database uses 0-based, half-open coordinates for genomic coordinates in the GRCh38 (human) and GRCm39 (mouse) reference genomes. Data is licensed under the Creative Commons license and the software is licensed under the MIT license. version: 1.2.0 - DEV servers: - url: https://catalog-api-dev.demo.igvf.org/api security: [] externalDocs: url: https://api-dev.catalog.igvf.org/openapi paths: /genes/variants: get: summary: Genes Variants description: >- Retrieve variant-gene pairs including eQTLs & splice QTLs from AFGR and eQTL Catalogue, and CRISPR screen and Variant-EFFECTS from IGVF, by Ensembl gene ids. The following parameters can be used to set thresholds on -log10 p_value: gt (>), gte (>=), lt (\<), lte (\<=). Set verbose = true to retrieve full info on the corresponding variants and genes. At least one of these properties must be defined: gene_id, hgnc_id, gene_name, region, alias, method, or files_fileset. The limit parameter controls the page size and can not exceed 500. Pagination is 0-based. **Examples by method** These examples are grouped by method; use the `method` filter to return data from a specific method. **eQTL:** **Single result** - gene_id = ENSG00000187642 - neg_log10_pvalue = gte:24.5 - method = eQTL **Group results** - alias = PERM1 - method = eQTL **spliceQTL:** **Single result** - gene_id = ENSG00000188976 - neg_log10_pvalue = gt:45 - effect_size = gt:0.5 - method = spliceQTL **Group results** - alias = NOC2L - method = spliceQTL **Variant-EFFECTS:** **Single result** - gene_id = ENSG00000108179 - neg_log10_pvalue = gt:13.1 - method = Variant-EFFECTS **Group results** - alias = PPIF - method = Variant-EFFECTS **CRISPR screen:** **query by gene identifier** - gene_id = ENSG00000177455 - method = CRISPR screen **query by gene name** - gene_name = CD19 - method = CRISPR screen operationId: variantsFromGenes parameters: - name: gene_id in: query required: false schema: type: string - name: hgnc_id in: query required: false schema: type: string - name: gene_name in: query required: false schema: type: string - name: alias in: query required: false schema: type: string - name: neg_log10_pvalue in: query required: false schema: type: string - name: effect_size in: query required: false schema: type: string - name: biosample_term in: query required: false schema: type: string - name: biological_context in: query required: false schema: type: string - name: label in: query required: false schema: type: string enum: - eQTL - spliceQTL - variant effect on gene expression - name: method in: query required: false schema: type: string enum: - CRISPR screen - Variant-EFFECTS - eQTL - spliceQTL - name: files_fileset in: query required: false schema: type: string - name: source in: query required: false schema: type: string enum: - AFGR - EBI - IGVF - name: name in: query required: false schema: type: string enum: - expression modulated by - splicing modulated by - name: organism in: query required: false schema: type: string enum: - Homo sapiens default: Homo sapiens - name: verbose in: query required: false schema: type: string enum: - 'true' - 'false' default: 'false' - name: page in: query required: false schema: type: number default: 0 - name: limit in: query required: false schema: type: number responses: '200': description: Successful response content: application/json: schema: type: array items: type: object properties: gene: anyOf: - type: string - type: object properties: _id: type: string chr: type: string start: type: number nullable: true end: type: number nullable: true gene_type: type: string nullable: true name: type: string strand: type: string nullable: true hgnc: type: string nullable: true entrez: type: string nullable: true collections: type: array items: type: string nullable: true study_sets: type: array items: type: string nullable: true source: type: string version: type: string source_url: type: string synonyms: type: array items: type: string nullable: true required: - _id - chr - start - end - gene_type - name - source - version - source_url additionalProperties: false nullable: true sequence_variant: anyOf: - type: string - type: object properties: _id: type: string chr: type: string pos: type: number rsid: type: array items: type: string nullable: true ref: type: string alt: type: string spdi: type: string hgvs: type: string ca_id: type: string nullable: true strain: type: array items: type: string nullable: true qual: type: string nullable: true files_filesets: type: string nullable: true annotations: type: object properties: bravo_af: type: number nullable: true gnomad_af_total: type: number nullable: true gnomad_af_afr: type: number nullable: true gnomad_af_afr_female: type: number nullable: true gnomad_af_afr_male: type: number nullable: true gnomad_af_ami: type: number nullable: true gnomad_af_ami_female: type: number nullable: true gnomad_af_ami_male: type: number nullable: true gnomad_af_amr: type: number nullable: true gnomad_af_amr_female: type: number nullable: true gnomad_af_amr_male: type: number nullable: true gnomad_af_asj: type: number nullable: true gnomad_af_asj_female: type: number nullable: true gnomad_af_asj_male: type: number nullable: true gnomad_af_eas: type: number nullable: true gnomad_af_eas_female: type: number nullable: true gnomad_af_eas_male: type: number nullable: true gnomad_af_female: type: number nullable: true gnomad_af_fin: type: number nullable: true gnomad_af_fin_female: type: number nullable: true gnomad_af_fin_male: type: number nullable: true gnomad_af_male: type: number nullable: true gnomad_af_nfe: type: number nullable: true gnomad_af_nfe_female: type: number nullable: true gnomad_af_nfe_male: type: number nullable: true gnomad_af_oth: type: number nullable: true gnomad_af_oth_female: type: number nullable: true gnomad_af_oth_male: type: number nullable: true gnomad_af_sas: type: number nullable: true gnomad_af_sas_male: type: number nullable: true gnomad_af_sas_female: type: number nullable: true gnomad_af_raw: type: number nullable: true GENCODE_category: type: string nullable: true funseq_description: type: string nullable: true additionalProperties: false nullable: true source: type: string source_url: type: string organism: type: string nullable: true required: - _id - chr - pos - ref - alt - annotations - source - source_url - organism additionalProperties: false nullable: true intron_chr: type: string nullable: true intron_start: type: string nullable: true intron_end: type: string nullable: true effect_size: type: number nullable: true neg_log10_pvalue: anyOf: - type: number - type: string nullable: true neg_log10_pvalue_adj: type: number nullable: true log2FC: type: number nullable: true posterior_inclusion_probability: type: number nullable: true coefficient_stddev: type: number nullable: true power: type: number nullable: true significant: type: boolean nullable: true standard_error: type: number nullable: true z_score: type: number nullable: true credible_set_min_r2: type: number nullable: true method: type: string nullable: true crispr_modality: type: string nullable: true source: type: string source_url: type: string label: type: string p_value: type: number nullable: true chr: type: string nullable: true biological_context: type: string biosample_term: type: string study: anyOf: - type: string - type: object properties: _id: type: string name: type: string ancestry_initial: type: string nullable: true ancestry_replication: type: string nullable: true n_cases: type: string nullable: true n_initial: type: string nullable: true n_replication: type: string nullable: true pmid: type: string nullable: true pub_author: type: string nullable: true pub_date: type: string nullable: true pub_journal: type: string nullable: true pub_title: type: string nullable: true has_sumstats: type: string nullable: true num_assoc_loci: type: string nullable: true study_source: type: string nullable: true trait_reported: type: string nullable: true trait_efos: type: string nullable: true trait_category: type: string nullable: true source: type: string study_type: type: string nullable: true version: type: string nullable: true required: - _id - name - ancestry_initial - ancestry_replication - n_cases - n_initial - n_replication - pmid - pub_author - pub_date - pub_journal - pub_title - has_sumstats - num_assoc_loci - study_source - trait_reported - trait_efos - trait_category - study_type - version additionalProperties: false nullable: true name: type: string nullable: true class: type: string nullable: true required: - gene - sequence_variant - source - source_url - label - biological_context - biosample_term additionalProperties: false default: $ref: '#/components/responses/error' components: responses: error: description: Error response content: application/json: schema: type: object properties: message: type: string code: type: string issues: type: array items: type: object properties: message: type: string required: - message additionalProperties: false required: - message - code additionalProperties: false ````