> ## Documentation Index > Fetch the complete documentation index at: https://docs.catalog.igvf.org/llms.txt > Use this file to discover all available pages before exploring further. # Variants Proteins > Retrieve allele-specific transcription factor binding events from ADASTRA in cell type-specific context, allele-specific transcription factor binding events from GVATdb, pQTL from UKB by querying variants, and predicted allele specific binding from SEMpl. Set verbose = true to retrieve full info on the variant-transcription factor pairs, and ontology terms of the cell types. At least one of these fields is required: variant_id, spdi, hgvs, rsid, ca_id, region, method, or files_fileset. The limit parameter controls the page size and can not exceed 100. Pagination is 0-based. **Examples by method** These examples are grouped by method; use the `method` filter to return data from a specific method. **ADASTRA:** **query by variant identifier** - variant_id = NC_000005.10:59317579:G:T - method = ADASTRA **query by region** - region = chr5:150575301-150575304 - method = ADASTRA **GVATdb:** **query by variant identifier** - variant_id = NC_000010.11:112626979:C:T - method = GVATdb **query by region** - region = chr10:112626978-112626982 - method = GVATdb **SEMVAR:** **query by variant identifier** - spdi = NC_000001.11:100091094:A:C - method = SEMVAR **query by region** - region = chr1:100091093-100091097 - method = SEMVAR **pQTL:** **query by variant identifier** - spdi = NC_000002.12:27508072:T:C - method = pQTL **query by region** - region = chr2:27508070-27508074 - method = pQTL ## OpenAPI ````yaml /openapi/catalog-dev.openapi.json get /variants/proteins openapi: 3.0.3 info: title: IGVF Catalog - Development description: >- Development IGVF Catalog OpenAPI compliant REST API built using tRPC with Express. Our database uses 0-based, half-open coordinates for genomic coordinates in the GRCh38 (human) and GRCm39 (mouse) reference genomes. Data is licensed under the Creative Commons license and the software is licensed under the MIT license. version: 1.2.0 - DEV servers: - url: https://catalog-api-dev.demo.igvf.org/api security: [] externalDocs: url: https://api-dev.catalog.igvf.org/openapi paths: /variants/proteins: get: summary: Variants Proteins description: >- Retrieve allele-specific transcription factor binding events from ADASTRA in cell type-specific context, allele-specific transcription factor binding events from GVATdb, pQTL from UKB by querying variants, and predicted allele specific binding from SEMpl. Set verbose = true to retrieve full info on the variant-transcription factor pairs, and ontology terms of the cell types. At least one of these fields is required: variant_id, spdi, hgvs, rsid, ca_id, region, method, or files_fileset. The limit parameter controls the page size and can not exceed 100. Pagination is 0-based. **Examples by method** These examples are grouped by method; use the `method` filter to return data from a specific method. **ADASTRA:** **query by variant identifier** - variant_id = NC_000005.10:59317579:G:T - method = ADASTRA **query by region** - region = chr5:150575301-150575304 - method = ADASTRA **GVATdb:** **query by variant identifier** - variant_id = NC_000010.11:112626979:C:T - method = GVATdb **query by region** - region = chr10:112626978-112626982 - method = GVATdb **SEMVAR:** **query by variant identifier** - spdi = NC_000001.11:100091094:A:C - method = SEMVAR **query by region** - region = chr1:100091093-100091097 - method = SEMVAR **pQTL:** **query by variant identifier** - spdi = NC_000002.12:27508072:T:C - method = pQTL **query by region** - region = chr2:27508070-27508074 - method = pQTL operationId: proteinsFromVariants parameters: - name: spdi in: query required: false schema: type: string - name: hgvs in: query required: false schema: type: string - name: rsid in: query required: false schema: type: string - name: ca_id in: query required: false schema: type: string - name: variant_id in: query required: false schema: type: string - name: region in: query required: false schema: type: string - name: label in: query required: false schema: type: string enum: - allele-specific binding - pQTL - predicted allele-specific binding - name: source in: query required: false schema: type: string enum: - ADASTRA - GVATdb - IGVF - UKB - name: method in: query required: false schema: type: string enum: - ADASTRA - GVATdb - SEMVAR - pQTL - name: files_fileset in: query required: false schema: type: string - name: name in: query required: false schema: type: string enum: - associated with levels of - modulates binding of - name: organism in: query required: false schema: type: string enum: - Homo sapiens default: Homo sapiens - name: verbose in: query required: false schema: type: string enum: - 'true' - 'false' default: 'false' - name: page in: query required: false schema: type: number default: 0 - name: limit in: query required: false schema: type: number responses: '200': description: Successful response content: application/json: schema: type: array items: type: object properties: sequence_variant: anyOf: - type: string - type: object properties: chr: type: string pos: type: number ref: type: string alt: type: string rsid: type: array items: type: string nullable: true spdi: type: string nullable: true hgvs: type: string nullable: true ca_id: type: string nullable: true _id: type: string required: - chr - pos - ref - alt additionalProperties: false protein_complex: anyOf: - anyOf: - type: string - type: object properties: _id: type: string name: type: string nullable: true uniprot_names: type: array items: type: string nullable: true uniprot_full_names: type: array items: type: string nullable: true uniprot_ids: type: array items: type: string nullable: true MANE_Select: type: boolean nullable: true organism: type: string source: type: string source_url: type: string required: - _id - organism - source - source_url additionalProperties: false - type: object properties: _id: type: string name: type: string alias: type: array items: type: string nullable: true molecules: type: array items: type: string nullable: true evidence_code: type: string nullable: true experimental_evidence: type: string nullable: true description: type: string nullable: true complex_assembly: anyOf: - type: string - type: array items: type: string nullable: true complex_source: type: string nullable: true reactome_xref: type: array items: type: string nullable: true source: type: string source_url: type: string required: - _id - name - source - source_url additionalProperties: false biosample_term: anyOf: - type: string - type: object properties: uri: type: string term_id: type: string name: type: string synonyms: type: array items: type: string nullable: true description: type: string nullable: true source: type: string subontology: type: string nullable: true source_url: type: string nullable: true required: - uri - term_id - name additionalProperties: false nullable: true biological_context: type: string nullable: true regulatory_type: type: string nullable: true class: type: string nullable: true label: type: string nullable: true name: type: string method: type: string nullable: true files_filesets: type: string nullable: true source: type: string nullable: true source_url: type: string nullable: true is_complex: type: boolean score: type: number nullable: true neg_log10_pvalue_adj_ref: type: number nullable: true neg_log10_pvalue_adj_alt: type: number nullable: true motif: type: string nullable: true motif_log2FC: type: number nullable: true beta: type: number nullable: true se: type: number nullable: true gene: type: string nullable: true gene_consequence: type: string nullable: true neg_log10_pvalue: type: number nullable: true p_value: type: number nullable: true neg_log10_pvalue_adj: type: number nullable: true variant_effect_score: type: number nullable: true SEMpl_annotation: type: string nullable: true SEMpl_baseline: type: number nullable: true alt_score: type: number nullable: true ref_score: type: number nullable: true relative_binding_affinity: type: number nullable: true effect_on_binding: type: string nullable: true required: - name - is_complex additionalProperties: false default: $ref: '#/components/responses/error' components: responses: error: description: Error response content: application/json: schema: type: object properties: message: type: string code: type: string issues: type: array items: type: object properties: message: type: string required: - message additionalProperties: false required: - message - code additionalProperties: false ````