Overview
This page provides comprehensive pharmacogenomic information about drugs, including genetic variants that influence drug response, efficacy, and adverse reactions. Drug information is sourced from PharmGKB and other pharmacogenomic databases.Drug Properties
This table displays basic properties and classifications for this drug.| Column | Description |
|---|---|
| Generic Name | Generic name of the drug |
| Brand Names | Commercial brand names |
| Drug Class | Therapeutic classification |
| Mechanism of Action | Primary mechanism of drug action |
| Indication | Primary therapeutic indications |
| Route of Administration | Method of drug delivery |
| Source | Source of drug information |
Associated Variants
This table shows genetic variants associated with this drug from PharmGKB, including information about drug response and pharmacogenomics.| Column | Description |
|---|---|
| Variant (rsID) | Reference SNP ID of the associated variant (click for variant details) |
| Gene Symbols | Genes associated with the drug-variant interaction |
| PMID | PubMed ID supporting the association (click to view publication) |
| Phenotype Categories | Categories of phenotypic effects or drug responses |
| Source | Source of the drug-variant association data (click for source details) |
Drug-Gene Interactions
This table shows genes that influence this drug’s pharmacokinetics or pharmacodynamics.| Column | Description |
|---|---|
| Gene | Gene symbol (click for gene details) |
| Interaction Type | Type of drug-gene interaction (metabolism, transport, target) |
| Effect | Effect on drug response (increased/decreased efficacy, toxicity) |
| Evidence Level | Level of evidence for the interaction |
| Population Frequency | Frequency of relevant variants in major populations |
| Clinical Annotation | Clinical recommendations based on genotype |
| Source | Source of the interaction data |
Dosing Guidelines
This table provides genotype-based dosing recommendations from clinical pharmacogenomics guidelines.| Column | Description |
|---|---|
| Gene | Gene affecting drug response |
| Genotype | Relevant genotype or phenotype |
| Recommendation | Dosing recommendation |
| Rationale | Scientific rationale for the recommendation |
| Population | Population group for the guideline |
| Guideline Source | Organization providing the guideline (CPIC, DPWG, etc.) |
| Evidence Level | Strength of evidence supporting the recommendation |
Adverse Drug Reactions
This table shows genetic associations with adverse drug reactions for this drug.| Column | Description |
|---|---|
| Variant | Genetic variant associated with adverse reaction |
| Adverse Reaction | Type of adverse drug reaction |
| Risk Level | Relative risk of adverse reaction |
| Population | Population where association was observed |
| Evidence Level | Strength of evidence |
| PMID | Supporting publications |
| Source | Source of the adverse reaction data |